Ascorbinsäure Thrombophlebitis

Ascorbinsäure Thrombophlebitis Ascorbinsäure wird in pflanzlichen Lebensmitteln, wie Kohl, Zitrusfrüchten, Hagebutten, Beeren, Kiefernnadeln. die von Thrombophlebitis leiden.

Ascorbinsäure Thrombophlebitis Venous Insufficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Venous Insufficiency malady Categories: Venous Insufficiency 12 29 42 14 Peripheral Venous Insufficiency Cardiovascular diseases See all MalaCards categories disease lists.

Diseases of veins, Ascorbinsäure Thrombophlebitis, lymphatic vessels and lymph nodes, not elsewhere classified. Other disorders of veins. Venous insufficiency chronic peripheral. Venous Insufficiency, also known as peripheral venous insufficiencyis related to lupus erythematosus and chronic venous insufficiency. The drugs Nitric Oxide and Carvedilol have been mentioned in the context of this disorder, Ascorbinsäure Thrombophlebitis.

Diseases in the Venous Insufficiency family: Graphical network of the top 20 diseases related to Venous Insufficiency: N,N''''-hexane-1,6-diylbis[N'- 4-chlorophenyl imidodicarbonimidic diamide ]. N',N'''''-hexane-1,6-diylbis[N- 4-chlorophenyl imidodicarbonimidic diamide ].

Nonaethylene glycol monolauryl ether. Heparin sodium 25, units in sodium chloride 0. Genetic tests related to Venous Insufficiency: Articles related to Venous Insufficiency: Differentiation of functional venous insufficiency and leg lymphedema complicated by functional venous insufficiency using subcutaneous tissue ultrasonography. Chronic cerebrospinal venous insufficiency: Lymphatic transport in patients with chronic venous insufficiency and venous leg ulcers following sequential pneumatic compression.

Randomized trial of radiofrequency ablation versus conventional surgery for superficial venous Ascorbinsäure Thrombophlebitis Venous compression syndrome of internal jugular veins prevalence in patients with multiple sclerosis and chronic cerebro-spinal venous insufficiency. Compression in the treatment of chronic venous insufficiency: Efficacy depending on the length of the stocking.

Aloe mit Varizen effects of short-term use of compression stockings on health related quality of life in patients with chronic venous insufficiency, Ascorbinsäure Thrombophlebitis. Physical exercise for the treatment of non-ulcerated chronic venous insufficiency. Primary venous insufficiency increases risk of deep vein thrombosis, Ascorbinsäure Thrombophlebitis.

Distally based subcutaneous veins for Ascorbinsäure Thrombophlebitis insufficiency of the reverse posterior interosseous artery flap. Response to letter regarding Embolization is not essential in the treatment of leg varices due to pelvic venous insufficiency, Ascorbinsäure Thrombophlebitis. Popliteal vein external banding at the valve-free segment to treat severe chronic venous insufficiency. Venous flow during manual lymphatic drainage applied to different regions of the lower extremity in people with and without chronic venous insufficiency: Endovenous Ascorbinsäure Thrombophlebitis ablation versus mechanochemical ablation with ClariVein Ar in the management Ascorbinsäure Thrombophlebitis superficial venous insufficiency LAMA trial: Phlebotonics for venous insufficiency, Ascorbinsäure Thrombophlebitis.

Letter regarding embolization is not essential in the treatment of Ascorbinsäure Thrombophlebitis varices due to pelvic venous insufficiency. A prospective comparison of a new cyanoacrylate glue and laser ablation for the treatment of venous insufficiency.

TCT High prevalence of pelvic venous compression syndrome among patients with chronic venous insufficiency and effective treatment with venous stenting. N-butyl cyanoacrylate in the treatment of venous insufficiency - the effect of embolisation with ablative polymerisation.

Chronic cerebrospinal venous Ascorbinsäure Thrombophlebitis as a cause of inner ear diseases. Advantages and disadvantages of graduated and inverse graduated compression hosiery in patients with chronic venous insufficiency and healthy volunteers: A prospective, mono-centric, blinded, open randomised, controlled and cross-over trial.

Progressive Ascorbinsäure Thrombophlebitis versus graduated compression for the management of venous insufficiency. The efficiency of O- beta-hydroxyethyl -rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfunction.

Doppler ultrasound study and venous mapping in chronic venous insufficiency. Effect of Ascorbinsäure Thrombophlebitis characteristics and clinical findings on the quality of life of patients with chronic venous insufficiency, Ascorbinsäure Thrombophlebitis. Sulodexide suppresses inflammation in patients with chronic venous insufficiency, Ascorbinsäure Thrombophlebitis. Clinical features of venous insufficiency and the risk of venous thrombosis in older people. Ascorbinsäure Thrombophlebitis Hylckama Vlieg A.

A randomized, double-blind, placebo-controlled, clinical study on Ascorbinsäure Thrombophlebitis efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency. Pregnancy-dependent blood flow velocity changes in lower extremities veins in venous insufficiency. Embolization is essential in the treatment of leg varicosities due to pelvic venous insufficiency. A systematic Ascorbinsäure Thrombophlebitis of the efficacy and tolerability of hydroxyethylrutosides for improvement of Ascorbinsäure Thrombophlebitis signs and symptoms of chronic venous insufficiency.

Adherence to and efficacy of different compression methods for treating chronic venous insufficiency in the elderly. New acoustic wave therapy improves quality of life in patients with multiple sclerosis and chronic cerebrospinal venous insufficiency. In vivo assessment of two endothelialization approaches on bioprosthetic valves for the treatment of chronic deep venous insufficiency.

Embolization is not essential in the treatment of leg varices due to Ascorbinsäure Thrombophlebitis venous insufficiency. A new option for endovascular treatment of leg ulcers caused by venous insufficiency with fluoroscopically guided sclerotherapy.

Quality of life in patients with venous stasis ulcers and others with advanced venous insufficiency, Ascorbinsäure Thrombophlebitis. Genes related to Venous Insufficiency 0 elite genes: Inhibition of Angiogenesis by TSP1 Transendothelial Migration of Leukocytes Cytokine Signaling in Immune system Signaling by Interleukins Ascorbinsäure Thrombophlebitis Degradation of the extracellular matrix Extracellular matrix organization Platelet activation, signaling and aggregation Selenium Micronutrient Network 1.

Vitamin B12 Metabolism 1. Formation of Fibrin Clot Clotting Cascade Blood Clotting Cascade 1, Ascorbinsäure Thrombophlebitis. Blood Coagulation Signaling Pathways Common Pathway of Fibrin Clot Formation Extrinsic Pathway of Fibrin Clot Formation Extrinsic Prothrombin Activation Pathway Intrinsic Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Fibronectin matrix formation Integrin cell surface interactions Fluid shear stress and atherosclerosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell adhesion molecules CAMs Complement and coagulation cascades 37 1.

Photodynamic therapy-induced NF-kB survival signaling 1. Immune response MIF-mediated glucocorticoid regulation Staphylococcus aureus infection Interleukin-4 and 13 signaling IL1 and megakaryocytes in obesity 1. LDL Oxidation in Atherogenesis Dissolution of Fibrin Clot The MalaCards human disease database index: Venous Insufficiency 12 29 42 14 69 Peripheral Venous Insufficiency Chronic Pulmonary Heart Disease.

Left Ventricular Outflow Tract Obstruction. Aethoxy-sklerol Laureth 9 Laureth-9 Macrogol 9 lauryl ether Nonaethylene glycol monododecyl ether. Nonaethylene glycol monolauryl ether PEG-9 lauryl ether Polydocanol Polyethylene glycol lauryl ether Polyoxyl 9 lauryl ether. Sodium 2-methylethylundecanolsulfate Sodium 7-ethylmethylundecanol sulfate. Micofenolico acido Mycophenoic acid Mycophenolate Mycophenolsäure Myfortic.

Advanced Chronic Venous Insufficiency. Disorders Publications show sections. Degradation of the extracellular matrix 62 Show member pathways Collagen degradation 62 Extracellular matrix organization

Decubitus Ulcer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Stickstoff enthaltende heterobicyclen als factor Ascorbinsäure Thrombophlebitis inhibitoren Nitrogen-containing factor xa inhibitors as heterobicycles translated from German DE T2. Verbindung der Formel A oder B: Compound of formula A or B: G ausgewählt ist aus: A compound according to claim 1, wherein: G is selected from: H, Y, XY; B is selected from: A compound according to claim 2, wherein: A compound according to claim 3, wherein: B ausgewählt ist aus XY, Ascorbinsäure Thrombophlebitis, einem Phenylrest, einem Pyrrolidinrest, einem Morpholinrest, einem 1,2,3-Triazolylrest und einem Imidazolylrest und substituiert ist mit 0 bis 1 Rest R 4a ; A compound according to claim 4, wherein: B ausgewählt ist aus: A compound according to claim 5, wherein: B is selected from: A compound according to claim 1, wherein the compound is selected from: A pharmaceutical composition comprising: Verbindung nach Anspruch 1, 2, 3, 4, 5, 6 Ascorbinsäure Thrombophlebitis 7 zur Verwendung in der Therapie.

A compound according Ascorbinsäure Thrombophlebitis claim 1, 2, 3, 4, 5, 6 or 7 for use in therapy. Verwendung der Verbindung nach Anspruch 1, 2, 3, 4, 5, Ascorbinsäure Thrombophlebitis, 6 oder 7 zur Herstellung eines Medikaments zur Behandlung einer thromboembolitischen Störung. Use of the compound according to claim 1, 2, Ascorbinsäure Thrombophlebitis, 4, 5, 6 or 7 for preparing a medicament Ascorbinsäure Thrombophlebitis treating a disorder thromboembolitischen, Ascorbinsäure Thrombophlebitis.

Diese Erfindung betrifft allgemein Stickstoff-enthaltende Heterobicyclen, welche Ascorbinsäure Thrombophlebitis von Trypsin-ähnlichen Serinprotease-Enzymen sind, speziell von Faktor Xa, Arzneimittel, welche diese enthalten und Verfahren, welche diese als antikoagulierende Mittel zur Behandlung und Vorbeugung thromboembolitischer Störungen verwenden.

This invention relates generally to nitrogen containing heterobicycles, which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing them, and methods using these thromboembolitischer as anticoagulant agents for treatment and prevention of disorders.

Ring E contains N atoms and M is Ascorbinsäure Thrombophlebitis variety of rings including pyrazole and triazole, is. Activated factor Xa, whose actual main role is the generation of thrombin by Ascorbinsäure Thrombophlebitis proteolysis of prothrombin, occupies a central position which combines the intrinsic and extrinsic activation mechanisms eventually common pathway of blood coagulation.

Probable role of the complex in the amplification of blood coagulation. Since it is calculated that one molecule of factor Xa can generate molecules of thrombin Elodi, S.

Probable role of the complex in the amplification of. Blood coagulation Thromb Res15, Deshalb werden wirkungsvolle und spezifische Inhibitoren für Faktor Xa als potentiell wertvolle therapeutische Mittel zur Behandlung von thromboembolitischen Störungen benötigt. Poultice von Kräutern für Krampfadern, potent and specific inhibitors of factor Xa are needed as potentially valuable therapeutic agents for the treatment of disorders thromboembolitischen.

Es ist daher wünschenswert, Ascorbinsäure Thrombophlebitis, neue Inhibitoren von Faktor Xa zu entdecken. It is thus desirable to discover new factor Xa inhibitors. Folglich ist eine Aufgabe der vorliegenden Erfindung, neue Stickstoff-enthaltende Heterobicyclen, welche als Inhibitoren von Faktor Xa nützlich sind, oder pharmazeutisch verträglichen Salze oder Prodrugs davon bereitzustellen.

Accordingly, an object of the present invention to provide novel nitrogen containing heterobicycles which are useful as inhibitors of factor Xa, or pharmaceutically acceptable salts or prodrugs thereof is provide. Another object of the present invention is to provide pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the invention Ascorbinsäure Thrombophlebitis a pharmaceutically acceptable salt or prodrug form thereof.

Ascorbinsäure Thrombophlebitis object of the present invention is to provide a method for the treatment of thromoembolitischen disorders, comprising administering an effective amount of at least one compounds of the invention or a pharmaceutically acceptable salt or prodrug thereof, to a host in need of such treatment.

Eine andere Aufgabe der vorliegenden Erfindung ist es, neue bicyclische Verbindungen zur Verwendung in der Therapie bereitzustellen. Another object of the present invention is to provide novel bicyclic compounds for use in therapy.

Eine andere Aufgabe der vorliegenden Betrieb Troyanova Thrombophlebitis ist es, die Verwendung neuer bicyclischer Verbindungen zur Herstellung eines Medikaments zur Behandlung einer thromboembolitischen Störung bereitzustellen. Another object of Ascorbinsäure Thrombophlebitis present invention is to provide the use of novel bicyclic compounds for preparing a medicament for treating a disorder thromboembolitischen.

Diese und weitere Aufgaben, welche in der folgenden detaillierten Beschreibung ersichtlich werden, sind durch die Entdeckung des Erfinders, dass Verbindungen der Formeln A und B These and other objects, which will become apparent in the following detailed description are by the discovery of the inventor that compounds of formulas A and B oder pharmazeutisch verträgliche Salz- oder Prodrugformen davon wirkungsvolle Inhibitoren Ascorbinsäure Thrombophlebitis Faktor Xa sind, erreicht worden, Ascorbinsäure Thrombophlebitis.

Y is selected Ascorbinsäure Thrombophlebitis U is in each occurrence selected from 0, 1, 2 and 3. B ausgewählt ist aus den Resten: B is selected from the radicals: Die hierin beschriebenen Verbindungen können asymmetrische Zentren aufweisen. The compounds described herein may have asymmetric centers, Ascorbinsäure Thrombophlebitis. Compounds of the invention containing an asymmetrically substituted atom may be isolated in optically active or racemic forms.

Im Fachgebiet ist gut bekannt, wie man optisch aktive Formen herstellt, wie zum Beispiel durch Auflösung racemischer Formen oder durch Synthese aus optisch aktiven Ausgangsmaterialien. In the art is well known how to prepare optically active forms, such as by resolution of racemic forms or by synthesis from optically active starting Ascorbinsäure Thrombophlebitis. Cis and trans geometric isomers of the compounds of the invention are described and may be isolated as a mixture of isomers or as separated isomeric forms.

Alle chiralen, diastereomeren, racemischen Formen und alle geometrischen isomeren Formen einer Struktur sind gewollt, ausser die spezifische stereochemische oder isomere Form ist besonders angegeben. Ketonal für Krampfadern chiral, diastereomeric, racemic forms and all geometric isomeric forms of a structure are intended, unless the specific stereochemistry Ascorbinsäure Thrombophlebitis isomeric form is specifically indicated.

All processes used to prepare compounds of the invention and intermediates produced thereby are Ascorbinsäure Thrombophlebitis part of the present invention, Ascorbinsäure Thrombophlebitis. The term "substituted", as used herein, means that the one or more hydrogen atoms are replaced at the indicated atom with a selection from the indicated group, provided that the normal valency of the atom indicated is not exceeded and the substitution results in a stable compound.

Ketosubstituenten liegen an aromatischen Einheiten nicht vor. There are no keto substituent of the aromatic units. The present invention is intended to include all isotopes of atoms occurring in the present compounds. Isotopes include those atoms that have the Ascorbinsäure Thrombophlebitis atomic number but different mass number.

For example, in general, without limitation, include isotopes of hydrogen and deuterium tritium. Isotopes of carbon include C and C a. Wenn eine Variable z. R 6 mehr als einmal in einer der Konstituenten oder Formeln einer Verbindung vorkommt, Ascorbinsäure Thrombophlebitis, ist ihre Definition Ascorbinsäure Thrombophlebitis jedem Vorkommen unabhängig von jedem weiteren Vorkommen.

If a variable Ascorbinsäure Thrombophlebitis. R 6 occurs Ascorbinsäure Thrombophlebitis than once in any of the constituents or formulas of a Ascorbinsäure Thrombophlebitis, its definition at Ascorbinsäure Thrombophlebitis occurrence is independent of any other occurrence.

Daher kann, falls zum Beispiel von einer Gruppe gezeigt wird, Ascorbinsäure Thrombophlebitis, dass sie mit 0 bis Meerwasser für Krampfadern R 6 substituiert ist, diese Gruppe gegebenenfalls mit bis zu zwei R 6 Gruppen substituiert werden, und R 6 wird bei jedem Vorkommen unabhängig von der Definition von R 6 ausgewählt werden.

Therefore, Ascorbinsäure Thrombophlebitis, if it is shown, Ascorbinsäure Thrombophlebitis, for example, by a group that is substituted with R 6, this group being optionally substituted with up to two R 6 groups are substituted, Ascorbinsäure Thrombophlebitis, and R 6 is independently from the definition of R 6, at each occurrence be selected. Falls von einer Bindung zu einem Substituenten gezeigt wird, dass sie eine Bindung kreuzt, die zwei Atome in einem Ring verbindet, dann kann ein derartiger Substituent an jedes Atom am Ring gebunden sein.

If it is shown by a bond to a Ascorbinsäure Thrombophlebitis that it crosses a bond connecting two atoms in a ring, then may be bonded to any atom on the ring such substituent.

Wenn ein Substituent Ascorbinsäure Thrombophlebitis ist, ohne dass das Atom angegeben ist, über welches ein derartiger Substituent mit dem Rest der Verbindung einer gegebenen Formel gebunden ist, dann kann ein derartiger Substituent über jedes Atom in einem derartigen Substituenten gebunden sein.

When a substituent is listed without the indicated atom via which such substituent is bonded to the remainder of the compound of a given formula, then may be bonded via any atom in such substituent such substituent, Ascorbinsäure Thrombophlebitis. As used herein, is intended to include both branched and straight-chain saturated aliphatic carbon hydrogen radicals, which have a specified number of carbon atoms, a "radical".

Examples of alkyl radicals include methyl, ethyl, n-propyl, i-propyl, Ascorbinsäure Thrombophlebitis, n-butyl, s-butyl, t-butyl, n-pentyl and s-pentyl group, a, are but not limited. Examples of Ascorbinsäure Thrombophlebitis include trifluoromethyl, trichloromethyl, pentafluoroethyl and Pentachlorethylgruppe, but are not limited thereto. Examples of alkoxy radicals include methoxy, ethoxy, n-propoxy, i-propoxy, n-butoxy, s-butoxy, t-butoxy, n-pentoxy, and s-pentoxy group, a, are but not limited.

An "alkynyl" is intended to include hydrocarbon chains having straight or branched configuration Ascorbinsäure Thrombophlebitis one or more triple carbon-carbon bonds which may occur in any stable point along the chain, such as ethynyl or propynyl. Ein "Halorest" oder "Halogenatom", wie er hierin verwendet wird, bezeichnet ein Fluor- Chlor- Ascorbinsäure Thrombophlebitis, Brom- und Iodatom; A "halo group" or "halogen", as used herein, refers to a fluorine, chlorine, bromine and iodine atom; und "Gegenion" wird verwendet, um kleine negativ geladene Spezies, wie zum Beispiel Chlorid, Bromid, Hydroxid, Acetat und Sulfat, darzustellen.

Wie hierin verwendet, soll "Carbocyclus" oder "carbocyclischer Rest" jede stabile 3- 4- Ascorbinsäure Thrombophlebitis, 5- 6- oder 7-gliedrige monocyclische oder bicyclische Verbindung oder 7- 8- 9- oder gliedrige bicyclische oder tricyclische Verbindung bedeuten, wobei jede davon gesättigt, teilweise ungesättigt oder aromatisch sein kann. As used herein, "carbocycle" or "carbocyclic residue" is any stable 3- Ascorbinsäure Thrombophlebitis, 4- 5- 6- or 7-membered monocyclic or bicyclic compound or 7- 8- 9- mean or membered bicyclic or tricyclic compound, each may be partially unsaturated or aromatic saturated thereof.

Examples of such carbocycles include cyclopropyl, cyclobutyl, Ascorbinsäure Thrombophlebitis, cyclopentyl, cyclohexyl, Ascorbinsäure Thrombophlebitis, adamantyl, cyclooctyl, [3. As used herein, the term "heterocycle" or "heterocyclic system" mean a stable 5- 6- or 7-membered monocyclic or bicyclic or a 7- mean 8- 9- or membered bicyclic heterocyclic ring which may be saturatedpartially unsaturated or unsaturated aromaticand which consists of carbon atoms and 1, 2, 3 or 4 hetero atoms consisting, which are independently selected from N, NH, O and S, and include any bicyclic group, defined wherein each of the above- heterocyclic rings is fused to a benzene ring.

Die Stickstoff- und Schwefelheteroatome können gegebenenfalls oxidiert sein. The nitrogen and sulfur heteroatoms may optionally be oxidized. Der heterocyclische Ring kann an den Rest, an den er gebunden ist, über jedes Heteroatom oder Kohlenstoffatom gebunden sein, was zu einer stabilen Struktur führt. Ascorbinsäure Thrombophlebitis heterocyclic ring may Behandlung von Krampfadern Kazan Preise attached to the rest, to which it is attached via any heteroatom or carbon atom which results in a stable structure.

Die hierin beschriebenen heterocyclischen Ringe können am Kohlenstoff- oder an einem Stickstoffatom substituiert sein, falls die so erhaltene Struktur stabil ist. The heterocyclic rings described herein may be substituted, if the structure thus obtained is stable on carbon or on a nitrogen atom. Ein Stickstoffatom im Heterocyclus kann gegebenenfalls quarternisiert sein. A nitrogen atom in the heterocycle may optionally be quaternized. Es wird bevorzugt, Ascorbinsäure Thrombophlebitis, dass wenn die Gesamtzahl von S- und O-Atomen im Heterocyclus eins überschreitet, diese Heteroatome vorzugsweise nicht benachbart zueinander sind.

It is preferred that when the total number of S and O atoms in Ascorbinsäure Thrombophlebitis heterocycle exceeds one, these heteroatoms are not adjacent to each Ascorbinsäure Thrombophlebitis preferably. It is preferred that the total number of S and O atoms in the heterocycle is not more than one.

Wie hierin verwendet, soll der Begriff "aromatisches heterocyclisches System" oder "Heteroarylrest" einen stabilen 5- 6- oder 7-gliedrigen monocyclischen oder bicyclischen oder einen 7- 8- Ascorbinsäure Thrombophlebitis, 9- oder gliedrigen bicyclischen heterocyclischen aromatischen Ring bedeuten, welcher aus Kohlenstoffatomen und aus 1, 2, 3 oder 4 unabhängig aus N, NH, Ascorbinsäure Thrombophlebitis, O und S ausgewählten Heteroatomen besteht.

As used herein, the term "aromatic heterocyclic system" or "heteroaryl Ascorbinsäure Thrombophlebitis mean a stable 5- 6- or 7-membered monocyclic or bicyclic or 7- 8- 9- or membered bicyclic heterocyclic aromatic ring which which consists of carbon atoms and from 1, 2, Ascorbinsäure Thrombophlebitis, 3 or 4 independently selected from N, NH, O, and S heteroatoms.

Es muss angemerkt werden, dass die Gesamtanzahl an S- und O-Atomen im aromatischen Heterocyclus nicht mehr als eins ist. It must be noted that the total number of S and O atoms in the aromatic heterocycle is not more than one.

Ebenso sind kondensierte Ringe und Spiroverbindungen, welche zum Beispiel vorstehende Heterocyclen enthalten, eingeschlossen. Likewise, condensed rings and spiro compounds containing, for example, above heterocycles included. Wie hierin verwendet, bezeichnet "pharmazeutisch verträgliche Salze" Derivate der offenbarten Verbindungen, wobei die Stammverbindung durch Erzeugen saurer oder basischer Salze davon modifiziert wird.

As used herein, "pharmaceutically acceptable salts" derivatives of the disclosed compounds wherein the parent compound is modified by generating acid or base salts thereof.

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